According to the Law of Bergonie and Tribondeau, which of the following characteristics make a cell more sensitive to radiation exposure? (Select three)

The Law of Bergonie and Tribondeau states that the sensitivity of cells to radiation is influenced by certain biological characteristics. Key factors that make cells more sensitive include their rate of division, their immaturity, and their lower degree of specialization.

When examining immaturity, younger or less differentiated cells tend to be more sensitive to radiation. This is because immature cells are typically in a rapid state of division and have a higher metabolic rate, making them more susceptible to the damaging effects of radiation.

The rate of division also plays a crucial role in cellular sensitivity. Cells that divide more frequently are at greater risk during exposure to radiation because they are undergoing mitosis, a process that can be disrupted by radiation, leading to lethal damage or mutations.

Furthermore, a lower degree of specialization allows cells to respond more dynamically to various stressors, including radiation. Specialized cells have already committed to specific functions, which can limit their ability to recover from damage caused by radiation.

Therefore, the characteristics of immaturity and the rate of division combined with a lower degree of specialization define why certain cells are more sensitive to radiation exposure. In this context, the correct identification of these factors is crucial for understanding radiation biology and its implications for radiation therapy or radiation exposure in general.